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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50402750
Substrate
n/a
Meas. Tech.
ChEMBL_886994 (CHEMBL2212889)
IC50
>50000±n/a nM
Citation
 Lee, K; Goo, JI; Jung, HY; Kim, M; Boovanahalli, SK; Park, HR; Kim, MO; Kim, DH; Lee, HS; Choi, Y Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors. Bioorg Med Chem Lett 22:7456-60 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
DGAT1_RAT | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
56890.70
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
498
Sequence:
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVREAAVSPDLGAGGDAPAPAPAPAHTRDKDRQTSVGDGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLSLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLIIASNIFIVATFQIEKRLSVGALTEQMGLLLHVVNLATIICFPAAVALLVESITPVGSLFALASYSIIFLKLSSYRDVNLWCRQRRVKAKAVSAGKKVSGAAAQNTVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRLGSNKWMARTGVFWASAFFHEYLVSIPLRMFRLWAFTAMMAQVPLAWIVNRFFQGNYGNAAVWVTLIIGQPVAVLMYVHDYYVLNYDAPVGA
  
Inhibitor
Name:
BDBM50402750
Synonyms:
CHEMBL2207811
Type:
Small organic molecule
Emp. Form.:
C20H17N3O3
Mol. Mass.:
347.3673
SMILES:
O=C(NCc1ccco1)c1ccc2nc(COc3ccccc3)[nH]c2c1
Structure:
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