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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50402767
Substrate
n/a
Meas. Tech.
ChEMBL_886994 (CHEMBL2212889)
IC50
23000±n/a nM
Citation
 Lee, K; Goo, JI; Jung, HY; Kim, M; Boovanahalli, SK; Park, HR; Kim, MO; Kim, DH; Lee, HS; Choi, Y Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors. Bioorg Med Chem Lett 22:7456-60 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
DGAT1_RAT | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 | Diglyceride acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
56890.70
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
498
Sequence:
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVREAAVSPDLGAGGDAPAPAPAPAHTRDKDRQTSVGDGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLSLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLIIASNIFIVATFQIEKRLSVGALTEQMGLLLHVVNLATIICFPAAVALLVESITPVGSLFALASYSIIFLKLSSYRDVNLWCRQRRVKAKAVSAGKKVSGAAAQNTVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRLGSNKWMARTGVFWASAFFHEYLVSIPLRMFRLWAFTAMMAQVPLAWIVNRFFQGNYGNAAVWVTLIIGQPVAVLMYVHDYYVLNYDAPVGA
  
Inhibitor
Name:
BDBM50402767
Synonyms:
CHEMBL2205735
Type:
Small organic molecule
Emp. Form.:
C26H28N2O3
Mol. Mass.:
416.5121
SMILES:
COC(=O)c1ccc2nc(COc3ccc(cc3)C34CC5CC(CC(C5)C3)C4)[nH]c2c1 |TLB:15:18:21.20.25:23,THB:19:20:23:27.18.26,19:18:21.20.25:23,26:18:21:25.24.23,26:24:21:27.19.18,15:18:21:25.24.23|
Structure:
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