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TargetEndoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
LigandBDBM50168990
Substrate/Competitorn/a
Meas. Tech.ChEMBL_885341
Ki 2620±n/a nM
Citation Moorthy, NSBrás, NFRamos, MJFernandes, PA Virtual screening and QSAR study of some pyrrolidine derivatives asa-mannosidase inhibitors for binding feature analysis. Bioorg Med Chem20:6945-59 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Name:Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:79590.42
Organism:Homo sapiens
Description:ChEMBL_885341
Residue:699
Sequence:
MAACEGRRSGALGSSQSDFLTPPVGGAPWAVATTVVMYPPPPPPPHRDFISVTLSFGENY
DNSKSWRRRSCWRKWKQLSRLQRNMILFLLAFLLFCGLLFYINLADHWKALAFRLEEEQK
MRPEIAGLKPANPPVLPAPQKADTDPENLPEISSQKTQRHIQRGPPHLQIRPPSQDLKDG
TQEEATKRQEAPVDPRPEGDPQRTVISWRGAVIEPEQGTELPSRRAEVPTKPPLPPARTQ
GTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVSRSFSEWFGLGLTLIDALDTMWI
LGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSGDSLFLRKAEDFGN
RLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQLEFRELSRLTGDKKFQEA
VEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARADSYYEYLLKQWIQGGKQE
TQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKMDHLVCFLPGTLALGVYHG
LPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPGRRDVEVKPADRHNLLRPET
VESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSINNVQDPQKPEPRDKMESFF
LGETLKYLFLLFSDDPNLLSLDAYVFNTEAHPLPIWTPA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50168990
NameBDBM50168990
Synonyms:(2R,3R,4S)-2-[((R)-Phenyl-1-(S)-2-hydroxy-2-phenyl-ethylamino)-methyl]-pyrrolidine-3,4-diol | CHEMBL361899
TypeSmall organic molecule
Emp. Form.C19H24N2O3
Mol. Mass.328.4055
SMILESO[C@@H]([C@@H](NC[C@H]1NC[C@H](O)[C@@H]1O)c1ccccc1)c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a