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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50044879
Substrate
n/a
Meas. Tech.
ChEMBL_205190 (CHEMBL812006)
Ki
9.0±n/a nM
Citation
 Abell, AD; Erhard, KF; Yen, H; Yamashita, DS; Brandt, M; Mohammed, H; Levy, MA; Holt, DA Preparative chiral HPLC separation of all possible stereoisomers of LY191704 and LY266111 and their in vitro inhibition of human types 1 and 2 steroid 5-reductases Bioorg Med Chem Lett 4:1365-1368 (1994)    Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
Enzyme
Mol. Mass.:
29472.80
Organism:
Homo sapiens (Human)
Description:
P18405
Residue:
259
Sequence:
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
  
Inhibitor
Name:
BDBM50044879
Synonyms:
(4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | 8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | CHEMBL29166 | LY-266111
Type:
Small organic molecule
Emp. Form.:
C15H18ClNO
Mol. Mass.:
263.763
SMILES:
CN1[C@@H]2CCc3cc(Cl)ccc3[C@@]2(C)CCC1=O
Structure:
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