Reaction Details Report a problem with these data
Target
Putative dihydropicolinate synthase
Ligand
BDBM50403312
Substrate
n/a
Meas. Tech.
ChEBML_54082
IC50
800000±n/a nM
Citation
 Couper, L; McKendrick, JE; Robins, DJ; Chrystal, EJ Pyridine and piperidine derivatives as inhibitors of dihydrodipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to l-lysine Bioorg Med Chem Lett 4:2267-2272 (1994)    Article 
Target
Name:
Putative dihydropicolinate synthase
Synonyms:
Dihydrodipicolinate synthase
Type:
PROTEIN
Mol. Mass.:
32147.51
Organism:
Streptomyces coelicolor
Description:
ChEMBL_54076
Residue:
298
Sequence:
MSETRKPWHGVIVATSLPFDDDLSVDFGAYGESVAHLAAQGMHGVAPNGSLGEYQTLTYEERDRVVETAVANAPEGFTVMPGVGAYGGREAERHARFAKDAGCQAVMCLPPNAYRADDRAVLQHFERVASVGLPVTAYNNPIDTKVDLRPDLLAKLHAEGYIVGVKEFSGDVRRCYEISELAPGLDLMIGTDDTVLEVALAGAKGWVAGYPQVFPRACLALYEASVRGDLEAALPLYRQLHPVLRWDSKTEFVQAIKLGQELTGRRGGPCRPPRQPLAPETEAVVRAATQALVDAGVN
  
Inhibitor
Name:
BDBM50403312
Synonyms:
CHEMBL73173
Type:
Small organic molecule
Emp. Form.:
C6H5NO3
Mol. Mass.:
139.1088
SMILES:
OC(=O)c1cccc[n+]1[O-]
Structure:
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