Reaction Details Report a problem with these data
Target
Putative dihydropicolinate synthase
Ligand
BDBM50000407
Substrate
n/a
Meas. Tech.
ChEBML_54082
IC50
1000000±n/a nM
Citation
 Couper, L; McKendrick, JE; Robins, DJ; Chrystal, EJ Pyridine and piperidine derivatives as inhibitors of dihydrodipicolinic acid synthase, a key enzyme in the diaminopimelate pathway to l-lysine Bioorg Med Chem Lett 4:2267-2272 (1994)    Article 
Target
Name:
Putative dihydropicolinate synthase
Synonyms:
Dihydrodipicolinate synthase
Type:
PROTEIN
Mol. Mass.:
32147.51
Organism:
Streptomyces coelicolor
Description:
ChEMBL_54076
Residue:
298
Sequence:
MSETRKPWHGVIVATSLPFDDDLSVDFGAYGESVAHLAAQGMHGVAPNGSLGEYQTLTYEERDRVVETAVANAPEGFTVMPGVGAYGGREAERHARFAKDAGCQAVMCLPPNAYRADDRAVLQHFERVASVGLPVTAYNNPIDTKVDLRPDLLAKLHAEGYIVGVKEFSGDVRRCYEISELAPGLDLMIGTDDTVLEVALAGAKGWVAGYPQVFPRACLALYEASVRGDLEAALPLYRQLHPVLRWDSKTEFVQAIKLGQELTGRRGGPCRPPRQPLAPETEAVVRAATQALVDAGVN
  
Inhibitor
Name:
BDBM50000407
Synonyms:
2-carboxypyridine | CHEMBL72628 | alpha-picolinic acid | alpha-pyridinecarboxylic acid | o-pyridinecarboxylic acid | picolinic acid | pyridine-2-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C6H5NO2
Mol. Mass.:
123.1094
SMILES:
OC(=O)c1ccccn1
Structure:
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