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Target
Growth hormone-releasing hormone receptor
Ligand
BDBM50403628
Substrate
n/a
Meas. Tech.
ChEBML_193173
EC50
3±n/a nM
Citation
 Tata, JR; Lu, Z; Jacks, TM; Schleim, KD; Cheng, K; Wei, L; Chan, WW; Butler, B; Tsou, N; Leung, K; Chiu, S; Hickey, G; Smith, RG; Patchett, AA The design and synthesis of orally active short duration spiroindane growth hormone secretagogues Bioorg Med Chem Lett 7:2319-2324 (1997)    Article 
Target
Name:
Growth hormone-releasing hormone receptor
Synonyms:
GHRH receptor | GHRHR_RAT | GRF receptor | Ghrhr | Grfr
Type:
PROTEIN
Mol. Mass.:
51523.38
Organism:
Rattus norvegicus
Description:
ChEMBL_193173
Residue:
464
Sequence:
MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
  
Inhibitor
Name:
BDBM50403628
Synonyms:
L-692585
Type:
Small organic molecule
Emp. Form.:
C32H37N7O3
Mol. Mass.:
567.6813
SMILES:
C[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)C1=O
Structure:
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