Target
Protein c-Fos/Transcription factor Jun
Ligand
BDBM50090435
Substrate
n/a
Meas. Tech.
ChEMBL_92286 (CHEMBL705832)
IC50
300±n/a nM
Citation
 Palanki, MSErdman, PEManning, AMOw, ARansone, LJSpooner, CSuto, CSuto, M Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett 10:1645-8 (2000) [PubMed]  Article 
Target
Name:
Protein c-Fos/Transcription factor Jun
Synonyms:
Proto-oncogene c-JUN/protein c-fos | Transcription factor AP1
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 305353
Components:
This complex has 2 components.
Component 1
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Component 2
Name:
Protein c-Fos
Synonyms:
FOS | FOS_HUMAN | G0S7 | Transcription factor AP1
Type:
PROTEIN
Mol. Mass.:
40679.34
Organism:
Homo sapiens (Human)
Description:
EBI_100167
Residue:
380
Sequence:
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL
  
Inhibitor
Name:
BDBM50090435
Synonyms:
3-Methyl-1-[5-(3-methyl-isoxazol-5-yl)-2-thiophen-2-yl-pyrimidin-4-ylamino]-pyrrole-2,5-dione | 3-methyl-1-(5-(3-methylisoxazol-5-yl)-2-(thiophen-2-yl)pyrimidin-4-ylamino)-1H-pyrrole-2,5-dione | CHEMBL45261
Type:
Small organic molecule
Emp. Form.:
C17H13N5O3S
Mol. Mass.:
367.382
SMILES:
CC1=CC(=O)N(Nc2nc(ncc2-c2cc(C)no2)-c2cccs2)C1=O |t:1|
Structure:
Search PDB for entries with ligand similarity: