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Target
ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial
Ligand
BDBM50404293
Substrate
n/a
Meas. Tech.
ChEMBL_65922 (CHEMBL678317)
IC50
82±n/a nM
Citation
 Atwal, KS; Ahmad, S; Ding, CZ; Stein, PD; Lloyd, J; Hamann, LG; Green, DW; Ferrara, FN; Wang, P; Rogers, WL; Doweyko, LM; Miller, AV; Bisaha, SN; Schmidt, JB; Li, L; Yost, KJ; Lan, HJ; Madsen, CS N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase. Bioorg Med Chem Lett 14:1027-30 (2004) [PubMed]  Article 
Target
Name:
ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial
Synonyms:
Mitochondrial complex V; ATP synthase
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 65924
Components:
This complex has 4 components.
Component 1
Name:
ATP synthase subunit epsilon, mitochondrial
Synonyms:
ATP5E | ATP5E_BOVIN | ATP5F1E | ATPase subunit epsilon
Type:
PROTEIN
Mol. Mass.:
5790.87
Organism:
Bos taurus
Description:
EBI_100264
Residue:
51
Sequence:
MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAMKTSGSTIKIVKVKKE
  
Component 2
Name:
ATP synthase subunit beta, mitochondrial
Synonyms:
ATP5B | ATP5F1B | ATPB_BOVIN
Type:
PROTEIN
Mol. Mass.:
56271.25
Organism:
Bos taurus
Description:
EBI_100264
Residue:
528
Sequence:
MLGLVGRVVAASASGALRGLSPSAPLPQAQLLLRAAPAALQPARDYAAQASPSPKAGATTGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHS
  
Component 3
Name:
ATP synthase subunit gamma, mitochondrial
Synonyms:
ATP5C | ATP5C1 | ATP5F1C | ATPG_BOVIN | F-ATPase gamma subunit
Type:
PROTEIN
Mol. Mass.:
33081.70
Organism:
Bos taurus
Description:
ChEMBL_65923
Residue:
298
Sequence:
MFSRAGVAGLSAWTVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARVYGVGSLALYEKADIKTPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKSEAANLAAAGKEVKIIGVGDKIRSILHRTHSDQFLVTFKEVGRRPPTFGDASVIALELLNSGYEFDEGSIIFNRFRSVISYKTEEKPIFSLDTISSAESMSIYDDIDADVLRNYQEYSLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
  
Component 4
Name:
ATP synthase subunit delta, mitochondrial
Synonyms:
ATP5D | ATP5F1D | ATPD_BOVIN | F-ATPase delta subunit
Type:
PROTEIN
Mol. Mass.:
17608.84
Organism:
Bos taurus
Description:
EBI_100264
Residue:
168
Sequence:
MLPSALLRRPGLGRLVRQVRLYAEAAAAQAPAAGPGQMSFTFASPTQVFFNSANVRQVDVPTQTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSVTVNADSSVQLLAEEAVTLDMLDLGAAKANLEKAQSELLGAADEATRAEIQIRIEANEALVKALE
  
Inhibitor
Name:
BDBM50404293
Synonyms:
CHEMBL8024
Type:
Small organic molecule
Emp. Form.:
C25H20Cl4N4O
Mol. Mass.:
534.265
SMILES:
OC(C(Nc1ccc(Cl)cc1)=NC(Cn1ccnc1)c1ccc(Cl)cc1Cl)c1ccc(Cl)cc1 |w:11.12|
Structure:
Search PDB for entries with ligand similarity: