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Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50367004
Substrate
n/a
Meas. Tech.
ChEBML_89668
Ki
137000±n/a nM
Citation
 Skibo, EB; Meyer, RB Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides. J Med Chem 24:1155-61 (1982) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
IMDH_ECOLI | guaB | guaR
Type:
PROTEIN
Mol. Mass.:
52020.85
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_89670
Residue:
488
Sequence:
MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKESPNYRLGS
  
Inhibitor
Name:
BDBM50367004
Synonyms:
CHEMBL603973
Type:
Small organic molecule
Emp. Form.:
C16H18N5O7PS
Mol. Mass.:
455.382
SMILES:
Nc1ncnc2n(C3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c(Sc3ccccc3)nc12 |r|
Structure:
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