Reaction Details Report a problem with these data
Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50367018
Substrate
n/a
Meas. Tech.
ChEBML_89668
Ki
52000±n/a nM
Citation
 Skibo, EB; Meyer, RB Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides. J Med Chem 24:1155-61 (1982) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
IMDH_ECOLI | guaB | guaR
Type:
PROTEIN
Mol. Mass.:
52020.85
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_89670
Residue:
488
Sequence:
MLRIAKEALTFDDVLLVPAHSTVLPNTADLSTQLTKTIRLNIPMLSAAMDTVTEARLAIALAQEGGIGFIHKNMSIERQAEEVRRVKKHESGVVTDPQTVLPTTTLREVKELTERNGFAGYPVVTEENELVGIITGRDVRFVTDLNQPVSVYMTPKERLVTVREGEAREVVLAKMHEKRVEKALVVDDEFHLIGMITVKDFQKAERKPNACKDEQGRLRVGAAVGAGAGNEERVDALVAAGVDVLLIDSSHGHSEGVLQRIRETRAKYPDLQIIGGNVATAAGARALAEAGCSAVKVGIGPGSICTTRIVTGVGVPQITAVADAVEALEGTGIPVIADGGIRFSGDIAKAIAAGASAVMVGSMLAGTEESPGEIELYQGRSYKSYRGMGSLGAMSKGSSDRYFQSDNAADKLVPEGIEGRVAYKGRLKEIIHQQMGGLRSCMGLTGCGTIDELRTKAEFVRISGAGIQESHVHDVTITKESPNYRLGS
  
Inhibitor
Name:
BDBM50367018
Synonyms:
CHEMBL605640
Type:
Small organic molecule
Emp. Form.:
C17H19N6O9PS
Mol. Mass.:
514.406
SMILES:
Nc1ncnc2n(C3OC(CO[P+](O)(O)[O-])C(O)C3O)c(SCc3ccc(cc3)[N+]([O-])=O)nc12
Structure:
Search PDB for entries with ligand similarity: