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Target
Histamine H2 receptor
Ligand
BDBM50404821
Substrate
n/a
Meas. Tech.
ChEBML_84894
Ki
4±n/a nM
Citation
 Lumma, WC; Anderson, PS; Baldwin, JJ; Bolhofer, WA; Habecker, CN; Hirshfield, JM; Pietruszkiewicz, AM; Randall, WC; Torchiana, ML; Britcher, SF; Clineschmidt, BV; Denny, GH; Hirschmann, R; Hoffman, MJ; Phillips, BT; Streeter, KB Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists. J Med Chem 25:207-10 (1982) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40567.22
Organism:
Cavia porcellus (domestic guinea pig)
Description:
For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:
359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
  
Inhibitor
Name:
BDBM50404821
Synonyms:
CHEMBL306465
Type:
Small organic molecule
Emp. Form.:
C17H25N5O2S
Mol. Mass.:
363.478
SMILES:
Nc1ns(=O)nc1NCCCOc1cccc(CN2CCCCC2)c1
Structure:
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