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TargetCholine Acetyltransferase
LigandBDBM50405549
Substrate/Competitorn/a
Meas. Tech.ChEMBL_49116
IC50 21000±n/a nM
Citation DeBernardis, JFGifford, PRizk, MErtel, RAbraham, DJSiuda, JF Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase. J Med Chem31:117-21 (1988) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Choline Acetyltransferase
Name:Choline acetylase
Synonyms:Choline O-acetyltransferase
Type:Enzyme Catalytic Domain
Mol. Mass.:71875.58
Organism:RAT
Description:Choline Acetyltransferase 0 RAT::P32738
Residue:640
Sequence:
MPILEKAPQKMPVKASSWEELDLPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAIVKR
FGAPGGLGETLQEKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFQDT
NDQLRFAACLISGVLSYKTLLDSHSLPTDWAKGQLSGQPLCMKQYYRLFSSYRLPGHTQD
TLVAQKSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLP
PIGLLTSDGRSEWAKARTVLLKDSTNRDSLDMIERCICLVCLDGPGTGELSDTHRALQLL
HGGGCSLNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMMTSNKKL
VRADSVSELPAPRRLRLKCSPETQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQK
YSPDGFIQVALQLAYYRLYQRLVPTYESASIRRFQEGRVDNIRSATPEALAFVQAMTDHK
AAMPASEKLQLLQTAMQAHKQYTVMAITGMAIDNHLLALRELARDLCKEPPEMFMDETYL
MSNRFVLSTSQVPTTMEMFCCYGPVVPNGNGACYNPQPEAITFCISSFHSCKETSSVEFA
EAVGASLVDMRDLCSSRQPADSKPPAPKEKARGPSQAKQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50405549
NameBDBM50405549
Synonyms:CHEMBL278309
TypeSmall organic molecule
Emp. Form.C24H24NO4
Mol. Mass.390.4511
SMILESCCOC(=O)C(C(=O)OCC)[n+]1ccc(\C=C\c2cccc3ccccc23)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a