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Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50405783
Substrate
n/a
Meas. Tech.
ChEMBL_100146 (CHEMBL712503)
Ki
2.2±n/a nM
Citation
 Haviv, F; Palabrica, CA; Bush, EN; Diaz, G; Johnson, ES; Love, S; Greer, J Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone. J Med Chem 32:2340-4 (1989) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LH/CG-R | LSH-R | LSHR_RAT | Lhcgr | Luteinizing hormone receptor | Luteinizing hormone/Choriogonadotropin receptor | Lutropin-choriogonadotropic hormone receptor
Type:
PROTEIN
Mol. Mass.:
78049.26
Organism:
Rattus norvegicus
Description:
ChEMBL_97289
Residue:
700
Sequence:
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
  
Inhibitor
Name:
BDBM50405783
Synonyms:
CHEMBL2369807
Type:
Small organic molecule
Emp. Form.:
C54H69N11O9
Mol. Mass.:
1016.194
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1cccc2ccccc12 |wU:5.4,31.32,45.48,23.24,wD:57.61,12.13,(27.95,-13.77,;26.48,-13.39,;26.09,-11.88,;24.61,-11.5,;23.49,-12.58,;24.2,-9.99,;25.18,-8.8,;24.35,-7.52,;22.85,-7.9,;22.76,-9.44,;21.44,-8.67,;21.46,-7.13,;20.11,-9.44,;20.09,-10.98,;21.41,-11.77,;21.4,-13.31,;22.72,-14.09,;22.69,-15.63,;21.37,-16.37,;24.03,-16.4,;18.77,-8.64,;17.43,-9.44,;17.46,-10.98,;16.1,-8.67,;16.08,-7.13,;17.4,-6.36,;18.75,-7.1,;17.4,-4.82,;14.77,-9.46,;13.42,-8.7,;13.42,-7.16,;12.1,-9.47,;12.1,-11.01,;13.45,-11.78,;14.86,-11.14,;15.89,-12.29,;15.14,-13.61,;15.63,-15.09,;14.61,-16.24,;13.09,-15.94,;12.61,-14.48,;13.61,-13.31,;10.76,-8.73,;9.43,-9.51,;9.44,-11.05,;8.06,-8.74,;8.06,-7.2,;9.4,-6.42,;9.38,-4.88,;10.73,-4.09,;12.06,-4.85,;13.39,-4.07,;12.07,-6.39,;10.75,-7.16,;6.75,-9.53,;5.4,-8.77,;5.4,-7.23,;4.09,-9.56,;4.09,-11.08,;5.43,-11.85,;2.74,-8.79,;1.39,-9.57,;1.42,-11.11,;.06,-8.8,;-1.27,-9.59,;-1.25,-11.11,;-2.59,-11.88,;-3.94,-11.13,;-3.94,-9.59,;-5.25,-8.83,;-5.28,-7.29,;-3.94,-6.52,;-2.62,-7.28,;-2.6,-8.82,)|
Structure:
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