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Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50405762
Substrate
n/a
Meas. Tech.
ChEMBL_100146 (CHEMBL712503)
Ki
3.7±n/a nM
Citation
 Haviv, F; Palabrica, CA; Bush, EN; Diaz, G; Johnson, ES; Love, S; Greer, J Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone. J Med Chem 32:2340-4 (1989) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LH/CG-R | LSH-R | LSHR_RAT | Lhcgr | Luteinizing hormone receptor | Luteinizing hormone/Choriogonadotropin receptor | Lutropin-choriogonadotropic hormone receptor
Type:
PROTEIN
Mol. Mass.:
78049.26
Organism:
Rattus norvegicus
Description:
ChEMBL_97289
Residue:
700
Sequence:
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
  
Inhibitor
Name:
BDBM50405762
Synonyms:
CHEMBL2369798
Type:
Small organic molecule
Emp. Form.:
C54H69N11O9
Mol. Mass.:
1016.194
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1ccc2ccccc2c1 |wU:5.4,31.32,45.48,23.24,wD:57.61,12.13,(28.66,-14.42,;27.18,-14.02,;26.8,-12.52,;25.31,-12.13,;24.2,-13.2,;24.91,-10.63,;25.87,-9.44,;25.06,-8.15,;23.56,-8.53,;23.46,-10.07,;22.15,-9.3,;22.17,-7.76,;20.82,-10.07,;20.8,-11.61,;22.12,-12.39,;22.1,-13.93,;23.43,-14.73,;23.4,-16.27,;22.07,-17.01,;24.74,-17.05,;19.47,-9.28,;18.14,-10.07,;18.17,-11.61,;16.81,-9.31,;16.79,-7.77,;18.11,-6.99,;19.45,-7.74,;18.11,-5.45,;15.47,-10.08,;14.13,-9.34,;14.13,-7.8,;12.81,-10.12,;12.81,-11.66,;14.16,-12.42,;15.57,-11.79,;16.6,-12.91,;15.85,-14.26,;16.34,-15.73,;15.31,-16.88,;13.8,-16.57,;13.31,-15.11,;14.32,-13.93,;11.46,-9.35,;10.14,-10.14,;10.15,-11.68,;8.77,-9.38,;8.77,-7.83,;10.11,-7.04,;11.45,-7.81,;12.78,-7.03,;12.77,-5.49,;14.1,-4.69,;11.43,-4.73,;10.08,-5.5,;7.45,-10.15,;6.11,-9.4,;6.11,-7.86,;4.79,-10.18,;4.79,-11.72,;6.14,-12.48,;3.44,-9.41,;2.1,-10.2,;2.13,-11.75,;.77,-9.44,;-.57,-10.21,;-.55,-11.75,;-1.88,-12.52,;-3.23,-11.75,;-4.54,-12.52,;-5.86,-11.77,;-5.87,-10.23,;-4.54,-9.46,;-3.23,-10.21,;-1.89,-9.44,)|
Structure:
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