Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50063719
Substrate
n/a
Meas. Tech.
ChEMBL_21101 (CHEMBL633695)
Ki
1.585E0±n/a nM
KOFF
1.778E-5 s-1
KON
1.175E4 M-1s-1
Citation
 Krantz, A; Spencer, RW; Tam, TF; Liak, TJ; Copp, LJ; Thomas, EM; Rafferty, SP Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase. J Med Chem 33:464-79 (1990) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50063719
Synonyms:
2-Isopropylamino-5-methyl-benzo[d][1,3]oxazin-4-one | CHEMBL10756
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2
Mol. Mass.:
218.2518
SMILES:
CC(C)Nc1nc2cccc(C)c2c(=O)o1
Structure:
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