Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50405979
Substrate
n/a
Meas. Tech.
ChEMBL_53615 (CHEMBL858229)
Ki
263027±n/a nM
Citation
 Selassie, CD; Li, RL; Poe, M; Hansch, C On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. J Med Chem 34:46-54 (1991) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50405979
Synonyms:
CHEMBL53516
Type:
Small organic molecule
Emp. Form.:
C15H20N4O2
Mol. Mass.:
288.3449
SMILES:
CCc1cc(Cc2cnc(N)nc2N)cc(CO)c1CO
Structure:
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