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Reaction Details
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TargetHistamine H2 receptor
LigandBDBM50406654
Substrate/Competitorn/a
Meas. Tech.ChEMBL_85336
Kd 2089.3±n/a nM
Citation Miyashita, MMatsumoto, TMatsukubo, HIinuma, FTaga, FSekiguchi, HHamada, KOkamura, KNishino, K Synthesis and antiulcer activity of N-substituted N'-[3-[3-(piperidinomethyl)phenoxy]propyl]ureas: histamine H2-receptor antagonists with a potent mucosal protective activity. J Med Chem35:2446-51 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H2 receptor
Name:Histamine H2 receptor
Synonyms:Gastric receptor I | H2R | HISTAMINE H2 | Histamine H2-Gs alpha S
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40567.22
Organism:Cavia porcellus (domestic guinea pig)
Description:For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50406654
NameBDBM50406654
Synonyms:CHEMBL81597
TypeSmall organic molecule
Emp. Form.C20H33N3O2
Mol. Mass.347.4949
SMILESCC(C)(C)NC(=O)NCCCOc1cccc(CN2CCCCC2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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