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Target
Prostaglandin reductase 1
Ligand
BDBM50410832
Substrate
n/a
Meas. Tech.
ChEMBL_341692 (CHEMBL861403)
IC50
5000±n/a nM
Citation
 Gong, J; Neels, JF; Yu, X; Kensler, TW; Peterson, LA; Sturla, SJ Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity. J Med Chem 49:2593-9 (2006) [PubMed]  Article 
Target
Name:
Prostaglandin reductase 1
Synonyms:
Dig1 | Ltb4dh | NADP-dependent leukotriene B4 12-hydroxydehydrogenase | PTGR1_RAT | Ptgr1
Type:
PROTEIN
Mol. Mass.:
35721.48
Organism:
Rattus norvegicus
Description:
ChEMBL_341692
Residue:
329
Sequence:
MVQAKTWTLKKHFEGFPTDSNFELRTTELPPLNNGEVLLEALFLSVDPYMRVAAKKLKEGDSMMGEQVARVVESKNSAFPTGTIVVALLGWTSHSISDGNGLRKLPAEWPDKLPLSLALGTVGMPGLTAYFGLLDICGLKGGETVLVNAAAGAVGSVVGQIAKLKGCKVVGTAGSDEKVAYLKKLGFDVAFNYKTVKSLEEALRTASPDGYDCYFDNVGGEFSNTVILQMKTFGRIAICGAISQYNRTGPCPPGPSPEVIIYQQLRMEGFIVTRWQGEVRQKALTDLMNWVSEGKIRYHEYITEGFEKMPAAFMGMLKGDNLGKTIVKA
  
Inhibitor
Name:
BDBM50410832
Synonyms:
CHEMBL205439
Type:
Small organic molecule
Emp. Form.:
C14H16O2
Mol. Mass.:
216.2756
SMILES:
CC1=CC2=C(C)C3(CC3)[C@](C)(O)C(=O)C2=C1 |c:3,16,t:1|
Structure:
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