Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM76662
Substrate
n/a
Meas. Tech.
ChEMBL_417161 (CHEMBL909462)
IC50
1.58±n/a nM
Citation
 Novaroli, L; Daina, A; Favre, E; Bravo, J; Carotti, A; Leonetti, F; Catto, M; Carrupt, PA; Reist, M Impact of species-dependent differences on screening, design, and development of MAO B inhibitors. J Med Chem 49:6264-72 (2006) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM76662
Synonyms:
4-methyl-7-phenylmethoxy-1-benzopyran-2-one | 4-methyl-7-phenylmethoxy-chromen-2-one | 4-methyl-7-phenylmethoxychromen-2-one | 7-Benzyloxy-4-methyl-chromen-2-one | 7-benzoxy-4-methyl-coumarin | MLS001212241 | SMR000514539 | cid_728520
Type:
Small organic molecule
Emp. Form.:
C17H14O3
Mol. Mass.:
266.2913
SMILES:
Cc1cc(=O)oc2cc(OCc3ccccc3)ccc12
Structure:
Search PDB for entries with ligand similarity: