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Target
C3a anaphylatoxin chemotactic receptor
Ligand
BDBM50423000
Substrate
n/a
Meas. Tech.
ChEMBL_438727 (CHEMBL889062)
IC50
79±n/a nM
Citation
 Denonne, F; Binet, S; Burton, M; Collart, P; Dipesa, A; Ganguly, T; Giannaras, A; Kumar, S; Lewis, T; Maounis, F; Nicolas, JM; Mansley, T; Pasau, P; Preda, D; Stebbins, K; Volosov, A; Zou, D Discovery of new C3aR ligands. Part 1: arginine derivatives. Bioorg Med Chem Lett 17:3258-61 (2007) [PubMed]  Article 
Target
Name:
C3a anaphylatoxin chemotactic receptor
Synonyms:
AZ3B | C3AR | C3AR1 | C3AR_HUMAN | C3R1 | C3a-R | HNFAG09
Type:
PROTEIN
Mol. Mass.:
53864.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_642034
Residue:
482
Sequence:
MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYKFGLSSSLDYPDFYGDPLENRSLENIVQPPGEMNDRLDPSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYSNVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDYYNLGQFTDDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSTHCPSNNVISERNSTTV
  
Inhibitor
Name:
BDBM50423000
Synonyms:
CHEMBL231405
Type:
Small organic molecule
Emp. Form.:
C17H19ClN4O4
Mol. Mass.:
378.81
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-c1ccc(o1)-c1cccc(Cl)c1)-[#6](-[#8])=O
Structure:
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