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Target
Parathyroid hormone/parathyroid hormone-related peptide receptor
Ligand
BDBM50002931
Substrate
n/a
Meas. Tech.
ChEMBL_446293 (CHEMBL895396)
Ki
933±n/a nM
Citation
 McDonald, IM; Austin, C; Buck, IM; Dunstone, DJ; Gaffen, J; Griffin, E; Harper, EA; Hull, RA; Kalindjian, SB; Linney, ID; Low, CM; Patel, D; Pether, MJ; Raynor, M; Roberts, SP; Shaxted, ME; Spencer, J; Steel, KI; Sykes, DA; Wright, PT; Xun, W Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists. J Med Chem 50:4789-92 (2007) [PubMed]  Article 
Target
Name:
Parathyroid hormone/parathyroid hormone-related peptide receptor
Synonyms:
PTH/PTHr receptor | PTH/PTHrP type I receptor | PTH1 receptor | PTH1R | PTH1R_HUMAN | PTHR | PTHR1 | Parathyroid hormone 1 receptor | Parathyroid hormone receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66370.95
Organism:
Homo sapiens (Human)
Description:
PARATHYROID HT1 0 HUMAN::Q03431
Residue:
593
Sequence:
MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
  
Inhibitor
Name:
BDBM50002931
Synonyms:
CHEMBL388909
Type:
Small organic molecule
Emp. Form.:
C35H36N6O
Mol. Mass.:
556.6999
SMILES:
NC(=N)Nc1ccc(Cc2ccc(cc2)N2c3ccccc3C(=NN(Cc3ccccc3)C2=O)C2CCCCC2)cc1 |c:24|
Structure:
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