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Target
D(3) dopamine receptor
Ligand
BDBM50414563
Substrate
n/a
Meas. Tech.
ChEMBL_582203 (CHEMBL1059863)
Ki
0.631±n/a nM
Citation
 Holmes, IP; Micheli, F; Gaines, S; Lorthioir, O; Watson, SP; Fabio, RD; Gentile, G; Heidbreder, C; Savoia, C; Worby, A Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. Bioorg Med Chem Lett 19:4799-801 (2009) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50414563
Synonyms:
CHEMBL559873
Type:
Small organic molecule
Emp. Form.:
C19H22ClN3OS
Mol. Mass.:
375.915
SMILES:
Clc1cccc(c1)N1CCN(CCN2CCCc3sccc3C2)C1=O
Structure:
Search PDB for entries with ligand similarity: