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TargetEcdysone receptor
LigandBDBM50326776
Substrate/Competitorn/a
Meas. Tech.ChEMBL_582869
IC50 1.29±n/a nM
Citation Harada, TNakagawa, YAkamatsu, MMiyagawa, H Evaluation of hydrogen bonds of ecdysteroids in the ligand-receptor interactions using a protein modeling system. Bioorg Med Chem17:5868-73 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ecdysone receptor
Name:Ecdysone receptor
Synonyms:20-hydroxy-ecdysone receptor | 20E receptor | EcR | EcRH | Ecdysteroid receptor | NR1H1 | Nuclear receptor subfamily 1 group H member 1
Type:PROTEIN
Mol. Mass.:93857.12
Organism:Drosophila melanogaster
Description:ChEMBL_582869
Residue:878
Sequence:
MKRRWSNNGGFMRLPEESSSEVTSSSNGLVLPSGVNMSPSSLDSHDYCDQDLWLCGNESG
SFGGSNGHGLSQQQQSVITLAMHGCSSTLPAQTTIIPINGNANGNGGSTNGQYVPGATNL
GALANGMLNGGFNGMQQQIQNGHGLINSTTPSTPTTPLHLQQNLGGAGGGGIGGMGILHH
ANGTPNGLIGVVGGGGGVGLGVGGGGVGGLGMQHTPRSDSVNSISSGRDDLSPSSSLNGY
SANESCDAKKSKKGPAPRVQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKSAVYCC
KFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKMTTSP
SSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARNIPSLTYNQ
LAVIYKLIWYQDGYEQPSEEDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKG
LPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGMADN
IEDLLHFCRQMFSMKVDNVEYALLTAIVIFSDRPGLEKAQLVEAIQSYYIDTLRIYILNR
HCGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQ
SHLQITQEENERLERAERMRASVGGAITAGIDCDSASTSAAAAAAQHQPQPQPQPQPSSL
TQNDSQHQTQPQLQPQLPPQLQGQLQPQLQPQLQTQLQPQIQPQPQLLPVSAPVPASVTA
PGSLSAVSTSSEYMGGSAAIGPITPATTSSITAAVTASSTTSAVPMGNGVGVGVGVGGNV
SMYANAQTAMALMGVALHSHQEQLIGGVAVKSEHSTTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326776
NameBDBM50326776
Synonyms:2,3,14,20,22-PENTAHYDROXYCHOLEST-7-EN-6-ONE | CHEMBL549789 | Ponasterone A
TypeSmall organic molecule
Emp. Form.C27H44O6
Mol. Mass.464.6347
SMILESCC(C)CC[C@@H](O)[C@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C |r,t:15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a