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Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50414716
Substrate
n/a
Meas. Tech.
ChEMBL_583012 (CHEMBL1051850)
EC50
1.26±n/a nM
Citation
 McKinnell, RM; Armstrong, SR; Beattie, DT; Choi, SK; Fatheree, PR; Gendron, RA; Goldblum, A; Humphrey, PP; Long, DD; Marquess, DG; Shaw, JP; Smith, JA; Turner, SD; Vickery, RG A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists. J Med Chem 52:5330-43 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:
Enzyme
Mol. Mass.:
43767.54
Organism:
Homo sapiens (Human)
Description:
Q13639
Residue:
388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
  
Inhibitor
Name:
BDBM50414716
Synonyms:
CHEMBL561278
Type:
Small organic molecule
Emp. Form.:
C29H40ClN5O2
Mol. Mass.:
526.113
SMILES:
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCCCN(C)CCc2c[nH]c3ccccc23)CC1
Structure:
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