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TargetMuscarinic receptor 4
LigandBDBM50241132
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596262
Kd 6.46±n/a nM
Citation Scapecchi, SNesi, MMatucci, RBellucci, CBuccioni, MDei, SGuandalini, LManetti, DMartelli, CMartini, EMarucci, GOrlandi, FRomanelli, MNTeodori, ECirilli, R Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure. J Med Chem53:201-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic receptor 4
Name:Muscarinic receptor 4
Synonyms:GPM4
Type:PROTEIN
Mol. Mass.:52799.10
Organism:Cavia porcellus
Description:ChEMBL_596262
Residue:477
Sequence:
MANFTPGNGSSGNQSMRLVTAAHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNR
QLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVM
NLLIISFDRYFCVTKPLTYPARRTTKVAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVP
DNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKT
LAFLKSPLVKQSIKKPPPGAMAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSA
TQNTKERPATELSTTETTTPAVAAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVP
ATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVL
VNTFCRSCIPETMWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50241132
NameBDBM50241132
Synonyms:3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9-aza-tricyclo[3.3.1.0*2,4*]non-7-yl ester | 7-(3-Hydroxy-2-phenyl-propionyloxy)-9,9-dimethyl-3-oxa-9-azonia-tricyclo[3.3.1.0*2,4*]nonane | CHEMBL376897 | METHSCOPOLAMINE | Methyl scopolamine | N-METHYLSCOPOLAMINE
TypeSmall organic molecule
Emp. Form.C18H24NO4
Mol. Mass.318.3869
SMILESC[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1 |r,TLB:9:8:4.5.6:1,9:10:4.5.6:1,THB:11:5:1:8.10|
Structure
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n/a