Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50033330
Substrate
n/a
Meas. Tech.
ChEMBL_613511 (CHEMBL1072277)
Ki
1071.52±n/a nM
Citation
 Smits, RA; Adami, M; Istyastono, EP; Zuiderveld, OP; van Dam, CM; de Kanter, FJ; Jongejan, A; Coruzzi, G; Leurs, R; de Esch, IJ Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists. J Med Chem 53:2390-400 (2010) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50033330
Synonyms:
Benzyl-[2-(4-methyl-piperazin-1-yl)-quinazolin-4-yl]-amine | CHEMBL118572 | N-benzyl-2-(4-methylpiperazin-1-yl)quinazolin-4-amine | VUF-10246
Type:
Small organic molecule
Emp. Form.:
C20H23N5
Mol. Mass.:
333.4301
SMILES:
CN1CCN(CC1)c1nc(NCc2ccccc2)c2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: