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Target
Falcipain-2
Ligand
BDBM50415533
Substrate
n/a
Meas. Tech.
ChEMBL_612226 (CHEMBL1074166)
IC50
>100000±n/a nM
Citation
 Hans, RH; Guantai, EM; Lategan, C; Smith, PJ; Wan, B; Franzblau, SG; Gut, J; Rosenthal, PJ; Chibale, K Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett 20:942-4 (2010) [PubMed]  Article 
Target
Name:
Falcipain-2
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
55912.57
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50415533
Synonyms:
CHEMBL592268
Type:
Small organic molecule
Emp. Form.:
C20H18O4
Mol. Mass.:
322.3545
SMILES:
COc1ccc(\C=C\C(=O)c2ccc(OCC#C)cc2)c(OC)c1
Structure:
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