Target
Falcipain-2
Ligand
BDBM50415541
Substrate
n/a
Meas. Tech.
ChEMBL_612226 (CHEMBL1074166)
IC50
>100000±n/a nM
Citation
 Hans, RHGuantai, EMLategan, CSmith, PJWan, BFranzblau, SGGut, JRosenthal, PJChibale, K Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett 20:942-4 (2010) [PubMed]  Article 
Target
Name:
Falcipain-2
Synonyms:
n/a
Type:
Enzyme
Mol. Mass.:
55912.57
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50415541
Synonyms:
CHEMBL597017
Type:
Small organic molecule
Emp. Form.:
C21H20O5
Mol. Mass.:
352.3805
SMILES:
COc1ccc(C(=O)\C=C\c2ccc(OCC#C)cc2)c(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: