Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM50416603
Substrate
n/a
Meas. Tech.
ChEMBL_651721 (CHEMBL1228411)
IC50
3.16±n/a nM
Citation
 Abdi, MH; Beswick, PJ; Billinton, A; Chambers, LJ; Charlton, A; Collins, SD; Collis, KL; Dean, DK; Fonfria, E; Gleave, RJ; Lejeune, CL; Livermore, DG; Medhurst, SJ; Michel, AD; Moses, AP; Page, L; Patel, S; Roman, SA; Senger, S; Slingsby, B; Steadman, JG; Stevens, AJ; Walter, DS Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor. Bioorg Med Chem Lett 20:5080-4 (2010) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50416603
Synonyms:
CHEMBL1222883
Type:
Small organic molecule
Emp. Form.:
C14H14ClF3N2O2
Mol. Mass.:
334.721
SMILES:
CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: