Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM50417270
Substrate
n/a
Meas. Tech.
ChEMBL_676096 (CHEMBL1273090)
IC50
5.01±n/a nM
Citation
 Abberley, L; Bebius, A; Beswick, PJ; Billinton, A; Collis, KL; Dean, DK; Fonfria, E; Gleave, RJ; Medhurst, SJ; Michel, AD; Moses, AP; Patel, S; Roman, SA; Scoccitti, T; Smith, B; Steadman, JG; Walter, DS Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor. Bioorg Med Chem Lett 20:6370-4 (2010) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50417270
Synonyms:
CHEMBL1271656
Type:
Small organic molecule
Emp. Form.:
C19H18ClF3N4O2
Mol. Mass.:
426.82
SMILES:
CN1[C@@H](CN(C1=O)c1cccnc1C)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: