| Reaction Details |
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 | Report a problem with these data |
| Target | GRIA2 |
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| Ligand | BDBM50417556 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_699692 |
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| EC50 | 1000±n/a nM |
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| Citation |  Jamieson, C; Maclean, JK; Brown, CI; Campbell, RA; Gillen, KJ; Gillespie, J; Kazemier, B; Kiczun, M; Lamont, Y; Lyons, AJ; Moir, EM; Morrow, JA; Pantling, J; Rankovic, Z; Smith, L Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg Med Chem Lett21:805-11 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GRIA2 |
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| Name: | Glutamate receptor AMPA 1/2 |
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| Synonyms: | AMPA-selective glutamate receptor 2 | GluR-2 | GluR-B | GluR-K2 | Glutamate AMPA 2 | Glutamate receptor 2 | Glutamate receptor ionotropic AMPA | Glutamate receptor ionotropic, AMPA 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 98825.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glutamate AMPA 2 GRIA2 HUMAN::P42262 |
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| Residue: | 883 |
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| Sequence: | MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTP
HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG
THPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINV
GNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL
GFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALT
YDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNI
KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTT
ILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKI
WNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLD
PLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWF
SLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDL
SKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGK
YAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLL
DKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSR
AEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
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| BDBM50417556 |
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| Name | BDBM50417556 |
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| Synonyms: | CHEMBL1230591 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20F3NO3S |
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| Mol. Mass. | 387.417 |
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| SMILES | CC(C)S(=O)(=O)N[C@H]1Cc2ccc(Cc3ccc(o3)C(F)(F)F)cc2C1 |r| |
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| Structure |  |
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| n/a |
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