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Target
Vasopressin V1b receptor
Ligand
BDBM50417715
Substrate
n/a
Meas. Tech.
ChEMBL_700574 (CHEMBL1648393)
Ki
630.96±n/a nM
Citation
 Smethurst, CA; Borthwick, JA; Gaines, S; Watson, S; Green, A; Schulz, MJ; Burton, G; Buson, AA; Arban, R The characterization of a novel V1b antagonist lead series. Bioorg Med Chem Lett 21:92-6 (2010) [PubMed]  Article 
Target
Name:
Vasopressin V1b receptor
Synonyms:
AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor
Type:
Enzyme
Mol. Mass.:
46985.01
Organism:
Homo sapiens (Human)
Description:
P47901
Residue:
424
Sequence:
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
  
Inhibitor
Name:
BDBM50417715
Synonyms:
CHEMBL1643611
Type:
Small organic molecule
Emp. Form.:
C26H33N3O4S2
Mol. Mass.:
515.688
SMILES:
CCCCNCc1ccc(cc1)-c1nc(CN([C@@H]2CCOC2)S(=O)(=O)c2ccc(OC)cc2)cs1 |r|
Structure:
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