Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50418365
Substrate
n/a
Meas. Tech.
ChEMBL_746762 (CHEMBL1776931)
Ki
0.562±n/a nM
Citation
 Napier, S; Wishart, G; Arbuckle, W; Baker, J; Barn, D; Bingham, M; Brown, A; Byford, A; Claxton, C; Craighead, M; Buchanan, K; Fielding, L; Gibson, L; Goodwin, R; Goutcher, S; Irving, N; MacSweeney, C; Milne, R; Mort, C; Presland, J; Sloan, H; Thomson, F; Turnbull, Z; Young, T The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists. Bioorg Med Chem Lett 21:3163-7 (2011) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
46820.18
Organism:
Homo sapiens (Human)
Description:
P37288
Residue:
418
Sequence:
MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
  
Inhibitor
Name:
BDBM50418365
Synonyms:
CHEMBL1774024
Type:
Small organic molecule
Emp. Form.:
C26H29Cl2N3O2
Mol. Mass.:
486.433
SMILES:
Clc1ccc(C[C@@H](NC(=O)C2(CC2)c2ccc(Cl)cc2)C(=O)N[C@@H]2C[C@@H]3CC[C@H](C2)N3)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: