Target
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Ligand
BDBM50419079
Substrate
n/a
Meas. Tech.
ChEMBL_767270 (CHEMBL1825382)
IC50
25118.86±n/a nM
Citation
 McClure, KJMaher, MWu, NChaplan, SREckert, WALee, DHWickenden, ADHermann, MAllison, BHawryluk, NBreitenbucher, JGGrice, CA Discovery of a novel series of selective HCN1 blockers. Bioorg Med Chem Lett 21:5197-201 (2011) [PubMed]  Article 
Target
Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Synonyms:
BCNG-1 | BCNG1 | Brain cyclic nucleotide-gated channel 1 | HCN1 | HCN1_HUMAN
Type:
PROTEIN
Mol. Mass.:
98811.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_767270
Residue:
890
Sequence:
MEGGGKPNSSSNSRDDGNSVFPAKASATGAGPAAAEKRLGTPPGGGGAGAKEHGNSVCFKVDGGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPVQSPLAARTFHYASPTASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHPTVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAALPRESSSVLNTDPDAEKPRFASNL
  
Inhibitor
Name:
BDBM50419079
Synonyms:
CHEMBL1823673
Type:
Small organic molecule
Emp. Form.:
C22H26FN3O
Mol. Mass.:
367.4597
SMILES:
CN1CCN(CC1)C1(CNC(=O)c2ccccc2F)Cc2ccccc2C1
Structure:
Search PDB for entries with ligand similarity: