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Target
Aurora kinase B
Ligand
BDBM50419260
Substrate
n/a
Meas. Tech.
ChEMBL_772964 (CHEMBL1838852)
IC50
398±n/a nM
Citation
 Liddle, J; Atkinson, FL; Barker, MD; Carter, PS; Curtis, NR; Davis, RP; Douault, C; Dickson, MC; Elwes, D; Garton, NS; Gray, M; Hayhow, TG; Hobbs, CI; Jones, E; Leach, S; Leavens, K; Lewis, HD; McCleary, S; Neu, M; Patel, VK; Preston, AG; Ramirez-Molina, C; Shipley, TJ; Skone, PA; Smithers, N; Somers, DO; Walker, AL; Watson, RJ; Weingarten, GG Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg Med Chem Lett 21:6188-94 (2011) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50419260
Synonyms:
CHEMBL1834758
Type:
Small organic molecule
Emp. Form.:
C17H22N6O
Mol. Mass.:
326.3962
SMILES:
Cc1cccc(Nc2nc(N[C@H]3CCCNC3)ncc2C(N)=O)c1 |r|
Structure:
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