Target
Tyrosine-protein kinase SYK
Ligand
BDBM50419247
Substrate
n/a
Meas. Tech.
ChEMBL_772965 (CHEMBL1838853)
IC50
32±n/a nM
Citation
 Liddle, JAtkinson, FLBarker, MDCarter, PSCurtis, NRDavis, RPDouault, CDickson, MCElwes, DGarton, NSGray, MHayhow, TGHobbs, CIJones, ELeach, SLeavens, KLewis, HDMcCleary, SNeu, MPatel, VKPreston, AGRamirez-Molina, CShipley, TJSkone, PASmithers, NSomers, DOWalker, ALWatson, RJWeingarten, GG Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg Med Chem Lett 21:6188-94 (2011) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50419247
Synonyms:
CHEMBL1835071 | US8470835, 1
Type:
Small organic molecule
Emp. Form.:
C17H22N6O2
Mol. Mass.:
342.3956
SMILES:
Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: