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Target
Histamine H3 receptor
Ligand
BDBM50419593
Substrate
n/a
Meas. Tech.
ChEMBL_795214 (CHEMBL1936782)
Ki
1.48±n/a nM
Citation
 Bordi, F; Rivara, S; Dallaturca, E; Carmi, C; Pala, D; Lodola, A; Vacondio, F; Flammini, L; Bertoni, S; Ballabeni, V; Barocelli, E; Mor, M Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain. Eur J Med Chem 48:214-30 (2012) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50419593
Synonyms:
CHEMBL1934048
Type:
Small organic molecule
Emp. Form.:
C24H32N2
Mol. Mass.:
348.5243
SMILES:
C[C@@H]1CCCN1Cc1ccc(cc1)-c1ccc(CN2CCCCC2)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: