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Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Ligand
BDBM50390157
Substrate
n/a
Meas. Tech.
ChEMBL_834527 (CHEMBL2073576)
IC50
8.3±n/a nM
Citation
 Cutshall, NS; Onrust, R; Rohde, A; Gragerov, S; Hamilton, L; Harbol, K; Shen, HR; McKee, S; Zuta, C; Gragerova, G; Florio, V; Wheeler, TN; Gage, JL Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia. Bioorg Med Chem Lett 22:5595-9 (2012) [PubMed]  Article 
Target
Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Synonyms:
PDE10_MOUSE | Pde10a
Type:
PROTEIN
Mol. Mass.:
89407.64
Organism:
Mus musculus
Description:
ChEMBL_1458264
Residue:
790
Sequence:
MSNDSTEGTVGSCNATGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKTNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKADGFALYFLGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIGPFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGPAPSKSTPEKLNVKVED
  
Inhibitor
Name:
BDBM50390157
Synonyms:
CHEMBL2069698
Type:
Small organic molecule
Emp. Form.:
C23H25BrN4O4
Mol. Mass.:
501.373
SMILES:
COc1cc(\C=N\NC(=O)C(OC(C)C)c2ccc(cc2)-n2cccn2)cc(OC)c1Br
Structure:
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