Reaction Details Report a problem with these data
Target
Solute carrier organic anion transporter family member 1A1
Ligand
BDBM50410855
Substrate
n/a
Meas. Tech.
ChEMBL_839191 (CHEMBL2077862)
Ki
9270±n/a nM
Citation
 Shitara, Y; Sugiyama, D; Kusuhara, H; Kato, Y; Abe, T; Meier, PJ; Itoh, T; Sugiyama, Y Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res 19:147-53 (2002) [PubMed]  Article 
Target
Name:
Solute carrier organic anion transporter family member 1A1
Synonyms:
OATP-1 | Oatp1 | Oatp1a1 | Organic anion-transporting polypeptide 1 | SO1A1_RAT | Slc21a1 | Slco1a1 | Sodium-independent organic anion transporter 1 | Solute carrier family 21 member 1
Type:
PROTEIN
Mol. Mass.:
74188.94
Organism:
Rattus norvegicus
Description:
ChEMBL_838286
Residue:
670
Sequence:
MEETEKKIATQEGRLFSKMKVFLLSLTCACLTKSLSGVYMNSMLTQIERQFDISTSVAGLINGSFEIGNLFFIVFVSYFGTKLHRPVVIGIGCVIMGLGCLLMSLPHFFMGRYEYETTISPTGNLSSNSFLCMENRTQTLKPTQDPAECVKEMKSLMWICVMVGNIIRGIGETPIVPLGISYIEDFAKSENSPLYIGILEMGKVAGPIFGLLLGSYCAQIYVDIGSVNTDDLTITPSDTRWVGAWWIGFLVCAGVNILTSIPFFFLPKALPKKGQQENVAVTKDGKVEKYGGQAREENLGITKDFLTFMKRLFCNPIYMLFILTSVLQVNGFINKFTFLPKYLEQQYGKSTAEAIFLIGVYSLPPICLGYLIGGFIMKKFKITVKKAAYLAFCLSVFEYLLFLCHFMLTCDNAAVAGLTTSYKGVQHQLHVESKVLADCNTRCSCSTNTWDPVCGDNGVAYMSACLAGCKKFVGTGTNMVFQDCSCIQSLGNSSAVLGLCKKGPECANRLQYFLILTIIISFIYSLTAIPGYMVFLRCVKSEEKSLGVGLHTFCIRVFAGIPAPVYFGALIDRTCLHWGTLKCGQRGACRMYDINSFRHIYLGLPIALRGSSYLPAFFILILMRKFQFPGDIDSSATDHTEMMLGEKESEHTDVHGSPQVENDGELKTKL
  
Inhibitor
Name:
BDBM50410855
Synonyms:
CIN-QUIN | QUINIDEX | QUINIDINE SULFATE
Type:
Small organic molecule
Emp. Form.:
C20H24N2O2
Mol. Mass.:
324.4168
SMILES:
COc1ccc2nccc([C@H](O)[C@H]3CC4CCN3C[C@@H]4C=C)c2c1 |r,TLB:20:19:12.13:16.15|
Structure:
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