Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 6
Ligand
BDBM50022787
Substrate
n/a
Meas. Tech.
ChEMBL_836628 (CHEMBL2077470)
Ki
418000±n/a nM
Citation
 Hasegawa, M; Kusuhara, H; Sugiyama, D; Ito, K; Ueda, S; Endou, H; Sugiyama, Y Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions. J Pharmacol Exp Ther 300:746-53 (2002) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 6
Synonyms:
Oat1 | Organic anion transporter 1 | S22A6_RAT | Slc22a6 | rOAT1 | rROAT1 | renal organic anion transporter 1
Type:
PROTEIN
Mol. Mass.:
60784.17
Organism:
Rattus norvegicus
Description:
ChEMBL_838479
Residue:
551
Sequence:
MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEAWLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELTLSKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRGKQNQQQQEQQKQMMPLQASTQEKNGL
  
Inhibitor
Name:
BDBM50022787
Synonyms:
(+)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G) | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid anion (Penicillin G) | 3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid(penicillin G) | BICILLIN | PENICILLIN G | PENICILLIN G PROCAINE | PENICILLIN-2 | PERMAPEN | PFIZERPEN | PFIZERPEN-AS | benzylpenicillin
Type:
Small organic molecule
Emp. Form.:
C16H18N2O4S
Mol. Mass.:
334.39
SMILES:
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: