Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50299249
Substrate
n/a
Meas. Tech.
ChEMBL_839583 (CHEMBL2090479)
IC50
10±n/a nM
Citation
 Giraud, F; Akué-Gédu, R; Nauton, L; Candelon, N; Debiton, E; Théry, V; Anizon, F; Moreau, P Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors. Eur J Med Chem 56:225-236 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50299249
Synonyms:
1,10-Dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | CHEMBL583972 | US8481586, 3
Type:
Small organic molecule
Emp. Form.:
C15H10N2O
Mol. Mass.:
234.2527
SMILES:
O=Cc1c[nH]c2c1ccc1c3ccccc3[nH]c21
Structure:
Search PDB for entries with ligand similarity: