Reaction Details Report a problem with these data
Target
40S ribosomal protein S27
Ligand
BDBM50420398
Substrate
n/a
Meas. Tech.
ChEMBL_840521 (CHEMBL2089872)
IC50
3970±n/a nM
Citation
 Kusakabe, K; Ide, N; Daigo, Y; Itoh, T; Higashino, K; Okano, Y; Tadano, G; Tachibana, Y; Sato, Y; Inoue, M; Wada, T; Iguchi, M; Kanazawa, T; Ishioka, Y; Dohi, K; Tagashira, S; Kido, Y; Sakamoto, S; Yasuo, K; Maeda, M; Yamamoto, T; Higaki, M; Endoh, T; Ueda, K; Shiota, T; Murai, H; Nakamura, Y Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation. ACS Med Chem Lett 3:560-564 (2012) [PubMed]  Article 
Target
Name:
40S ribosomal protein S27
Synonyms:
MPS-1 | MPS1 | Metallopan-stimulin 1 | RPS27 | RS27_HUMAN
Type:
PROTEIN
Mol. Mass.:
9472.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446775
Residue:
84
Sequence:
MPLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
  
Inhibitor
Name:
BDBM50420398
Synonyms:
CHEMBL2089252
Type:
Small organic molecule
Emp. Form.:
C16H18N4O
Mol. Mass.:
282.3403
SMILES:
CCOc1nc(NCCc2ccccc2)cc(N)c1C#N
Structure:
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