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Target
Sonic hedgehog protein
Ligand
BDBM50421170
Substrate
n/a
Meas. Tech.
ChEMBL_839692 (CHEMBL2089519)
EC50
300±n/a nM
Citation
 Stappenbeck, F; Xiao, W; Epperson, M; Riley, M; Priest, A; Huang, D; Nguyen, K; Jung, ME; Thies, RS; Farouz, F Novel oxysterols activate the Hedgehog pathway and induce osteogenesis. Bioorg Med Chem Lett 22:5893-7 (2012) [PubMed]  Article 
Target
Name:
Sonic hedgehog protein
Synonyms:
Hhg1 | SHH_MOUSE | Shh
Type:
Protein
Mol. Mass.:
47784.50
Organism:
Mus musculus (Mouse)
Description:
Q62226
Residue:
437
Sequence:
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFLTFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQRVYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTWLLDSETMHPLGMAVKSS
  
Inhibitor
Name:
BDBM50421170
Synonyms:
CHEMBL2086775 | CHEMBL2086786
Type:
Small organic molecule
Emp. Form.:
C27H48O3
Mol. Mass.:
420.6682
SMILES:
CCCCCC[C@](C)(O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r|
Structure:
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