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Target
GTPase HRas
Ligand
BDBM50421182
Substrate
n/a
Meas. Tech.
ChEMBL_839704 (CHEMBL2089531)
Kd
158000±n/a nM
Citation
 Wang, W; Fang, G; Rudolph, J Ras inhibition via direct Ras binding--is there a path forward? Bioorg Med Chem Lett 22:5766-76 (2012) [PubMed]  Article 
Target
Name:
GTPase HRas
Synonyms:
GTPase HRas, N-terminally processed | H-Ras | H-Ras-1 | HRAS | HRAS1 | Ha-Ras | His6-Ha-Ras-CVLS | RASH_HUMAN | Transforming protein p21 | Transforming protein p21/H-Ras-1 | Wild-type Ha-Ras | c-H-ras | p21ras
Type:
Other Protein Type
Mol. Mass.:
21293.37
Organism:
Homo sapiens (Human)
Description:
P01112
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
  
Inhibitor
Name:
BDBM50421182
Synonyms:
CHEMBL2086797
Type:
Small organic molecule
Emp. Form.:
C92H142N22O27
Mol. Mass.:
1988.2431
SMILES:
CC[C@H](C)[C@H](NC(=O)CN1C\C=C/CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(O)=O)C1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O |r,c:11|
Structure:
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