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Targetβ-lactamase (Bla2)
LigandBDBM50421214
Substrate/Competitorn/a
Meas. Tech.ChEMBL_839906
Ki 5100±n/a nM
Citation Chen, PHorton, LBMikulski, RLDeng, LSundriyal, SPalzkill, TSong, Y 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-ß-lactamases. Bioorg Med Chem Lett22:6229-32 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
β-lactamase (Bla2)
Name:β-lactamase (Bla2)
Synonyms:BAS3245 | Beta-lactamase II | GBAA_3500 | bla2
Type:Enzyme
Mol. Mass.:28177.23
Organism:Bacillus anthracis
Description:Q93T40
Residue:256
Sequence:
MKNTLLKLGVCVSLLGITPFVSTISSVQAERKVEHKVIKNETGTISISQLNKNVWVHTEL
GYFNGEAVPSNGLILNTSKGLVLVDSSWDDKLTKELIEMAEKKFKKSVTDVIITHAHADR
IGGIKTLKERGIKAHSTTLTAELAKKNGYEEPLGDLQAITKLKFGNMKVETFYPGKGHTE
DNIVVWLPQYNMLVGGCLVKSASAKDLGNITDAYVNEWSTSIENVLKRYENINFVVPGHG
EVGDKGLLLHTLDLLK
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  Blast E-value cutoff:
BDBM50421214
NameBDBM50421214
Synonyms:CHEMBL2087633
TypeSmall organic molecule
Emp. Form.C10H10N2O2S
Mol. Mass.222.264
SMILESNc1cccc(c1)C1=N[C@@H](CS1)C(O)=O |r,t:8|
Structure
n/a