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Target
P2Y purinoceptor 12
Ligand
BDBM50423387
Substrate
n/a
Meas. Tech.
ChEMBL_457631 (CHEMBL923908)
IC50
0.50±n/a nM
Citation
 Springthorpe, B; Bailey, A; Barton, P; Birkinshaw, TN; Bonnert, RV; Brown, RC; Chapman, D; Dixon, J; Guile, SD; Humphries, RG; Hunt, SF; Ince, F; Ingall, AH; Kirk, IP; Leeson, PD; Leff, P; Lewis, RJ; Martin, BP; McGinnity, DF; Mortimore, MP; Paine, SW; Pairaudeau, G; Patel, A; Rigby, AJ; Riley, RJ; Teobald, BJ; Tomlinson, W; Webborn, PJ; Willis, PA From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. Bioorg Med Chem Lett 17:6013-8 (2007) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50423387
Synonyms:
CHEMBL437204
Type:
Small organic molecule
Emp. Form.:
C23H33N7O7S
Mol. Mass.:
551.616
SMILES:
CCCCNc1nc(SCCC)nc2n(nnc12)[C@@H]1C[C@H](\C=C\C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](O)[C@H]1O
Structure:
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