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TargetMatrix Metalloproteinase-8 (MMP-8)
LigandBDBM50102468
Substrate/Competitorn/a
Meas. Tech.ChEMBL_458937
IC50 1.2±n/a nM
Citation Verma, RPHansch, C Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem15:2223-68 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matrix Metalloproteinase-8 (MMP-8)
Name:Matrix Metalloproteinase-8 (MMP-8)
Synonyms:Collagenase 2 | MMP-8 | MMP8 | Matrix metalloproteinase-8 | Neutrophil collagenase | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:Enzyme
Mol. Mass.:53413.48
Organism:Homo sapiens (human)
Description:n/a
Residue:467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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  Blast E-value cutoff:
BDBM50102468
NameBDBM50102468
Synonyms:4-[Carboxy-(4'-methoxy-biphenyl-4-sulfonylamino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester | CHEMBL82169
TypeSmall organic molecule
Emp. Form.C25H32N2O7S
Mol. Mass.504.596
SMILESCOc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(C1CCN(CC1)C(=O)OC(C)(C)C)C(O)=O
Structure
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n/a