Reaction Details
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Report a problem with these dataTarget
Muscarinic acetylcholine receptor M1
Ligand
BDBM50423607
Substrate
n/a
Meas. Tech.
ChEMBL_469046 (CHEMBL929998)
pH
8±n/a
IC50
219±n/a nM
Comments
extracted
Citation
Kane, BE; Grant, MK; El-Fakahany, EE; Ferguson, DM Synthesis and evaluation of xanomeline analogs--probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor. Bioorg Med Chem 16:1376-92 (2008) [PubMed] Article More Info.:
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
Inhibitor
Name:
BDBM50423607
Synonyms:
CHEMBL408822
Type:
Small organic molecule
Emp. Form.:
C16H22N4OS
Mol. Mass.:
318.437
SMILES:
CN1CCC=C(C1)c1nsnc1OCCCCn1cccc1 |c:4|
Structure:
