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Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50358043
Substrate
n/a
Meas. Tech.
ChEMBL_936194 (CHEMBL2320151)
IC50
200000±n/a nM
Citation
 Suenkel, B; Fischer, F; Steegborn, C Inhibition of the human deacylase Sirtuin 5 by the indole GW5074. Bioorg Med Chem Lett 23:143-6 (2012) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50358043
Synonyms:
CHEMBL1794051 | GW-5074
Type:
Small organic molecule
Emp. Form.:
C15H10Br2INO2
Mol. Mass.:
522.958
SMILES:
OC1Nc2ccc(I)cc2C1=Cc1cc(Br)c(O)c(Br)c1
Structure:
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